182 research outputs found
Implementation of Automation System to Control Machine Voltage of Electroplating Process
Technology has been proliferating and it has been creating a new term in the world of technology. One of the new terms that have emerged along with technological development is The Fourth Industrial Revolution. In line with the revolution, this research has a purpose of creating a smart manufacturing concept that involves several components such as software, machines, and certain tools such as RFID. This research will be designed and developed using software development method in the form of a waterfall method and this research will use C# programming language released by American multinational technology company, which is Microsoft to create the software. This research will be assisted by several hardware devices such as RFID Reader that will serve as a tool that will read information stored in RFID Tag and RFID Tag that will be used to store information needed by system. The output of this research is a software that is capable of automating voltage adjustment of electroplating machine, monitor the voltage and ampere of the machine, and able to aid users on the electroplating proces
Assessment and risk prediction in patients with aortic stenosis: insights from cardiovascular magnetic resonance
BACKGROUND
Aortic stenosis affects not only the valve but also the myocardium. In
response to the increased afterload, left ventricular hypertrophy initially
occurs as a compensatory response to maintain wall stress and cardiac
output but ultimately, decompensation and heart failure ensues. The
transition from adaptation to decompensation is driven by myocyte death
and myocardial fibrosis. The aims of the thesis are to investigate
cardiovascular magnetic resonance assessment of disease severity and
myocardial fibrosis, and explore its relationship with other biomarkers of
disease activity and clinical outcome in patients with aortic stenosis.
METHODS AND RESULTS
The conventional assessment of aortic stenosis relies heavily on two-dimensional
and Doppler echocardiography but there are inherent
limitations in echocardiography that can affect the severity classification. I
demonstrated that cardiovascular magnetic resonance offered a more
accurate estimation of left ventricular volumes and mass, and excellent
myocardial characterization. Indeed, inaccurate stroke volume estimation by
Doppler echocardiography and inconsistent thresholds in current guidelines
accounted for more than 40% of patients with discordant small-area, lowgradient
aortic stenosis. These data may explain the variable prognosis
reported in this unique group of patients, and argue for more accurate
assessment of borderline cases with cardiovascular magnetic resonance.
Late gadolinium enhancement imaging detects focal areas of established
myocardial fibrosis. In many conditions, including aortic stenosis, a more
diffuse form of fibrosis predominates, which is potentially reversible and not
readily identified by late gadolinium enhancement. Recently several
myocardial T1 mapping approaches have been developed to quantify diffuse
fibrosis. Using a standardized and systematic approach, I compared several
commonly used T1 mapping techniques and identified that extracellular
volume had the best profile (reproducibility and discriminatory potential) for
the identification of diffuse fibrosis in patients with aortic stenosis.
Cardiac troponin is a structural protein present in the cardiac myocytes.
Recent advances in assay technology have substantially improved
sensitivity, allowing quantification of troponin concentrations with a high
degree of precision in everyone. In more than 250 patients with aortic
stenosis, I demonstrated that cardiac troponin I concentrations were
independently associated with markers of left ventricular decompensation
(hypertrophy and fibrosis) and predicted clinical outcome in patients with
aortic stenosis. This suggests that myocardial fibrosis detected by
cardiovascular magnetic resonance is consequent on myocardial injury
secondary to left ventricular decompensation.
Left ventricular hypertrophy with strain pattern on a 12-lead
electrocardiogram is associated with poor outcome in patients with aortic
stenosis, but the mechanism of this electrocardiographic pattern has not been
described. In more than 300 patients with aortic stenosis, I demonstrated
that these characteristic repolarization abnormalities were a highly specific
marker of focal mid-wall myocardial fibrosis (specificity of 99% and
sensitivity of 54%). Moreover, the prognostic value of this
electrocardiographic pattern was again confirmed with markedly worse
long-term outcomes in these patients.
CONCLUSION
I have demonstrated that cardiovascular magnetic resonance can assist in the
assessment of disease severity in patients with aortic stenosis and discordant
echocardiographic findings. Moreover, I have validated the assessment of
diffuse myocardial fibrosis, as well as, demonstrated the close association
between myocardial fibrosis and biomarkers of myocardial injury and
electrocardiographic strain pattern that predicted an adverse outcome in
patients with aortic stenosis
Plasma Desmosine and Abdominal Aortic Aneurysm Disease
Background It is recognized that factors beyond aortic size are important in predicting outcome in abdominal aortic aneurysm (AAA) disease. AAA is characterized by the breakdown of elastin within the aortic tunica media, leading to aortic dilatation and rupture. The aim of this study was to investigate the association of plasma desmosine (pDES), an elastin-specific degradation product, with disease severity and clinical outcome in patients with AAA. Methods and Results We measured pDES and serum biomarker concentrations in 507 patients with AAAs (94% men; mean age, 72.4±6.1 years; mean AAA diameter, 48±8 mm) and 162 control subjects (100% men; mean age, 71.5±4.4 years) from 2 observational cohort studies. In the longitudinal cohort study (n=239), we explored the incremental prognostic value of pDES on AAA events. pDES was higher in patients with AAA compared with control subjects (mean±SD: 0.46±0.22 versus 0.33±0.16 ng/mL; P<0.001) and had the strongest correlation with AAA diameter (r=0.39; P<0.0001) of any serum biomarker. After adjustment for baseline AAA diameter, pDES was associated with an AAA event (hazard ratio, 2.03 per SD increase [95% CI, 1.02-4.02]; P=0.044). In addition to AAA diameter, pDES provided incremental improvement in risk stratification (continuous net reclassification improvement, 34.4% [95% CI, -10.8% to 57.5%; P=0.09]; integrated discrimination improvement, 0.04 [95% CI, 0.00-0.15; P=0.050]). Conclusions pDES concentrations predict disease severity and clinical outcomes in patients with AAA. Clinical Trial Registration http://www.isrctn.com. Unique identifier: ISRCTN76413758
Sacubitril/valsartan versus valsartan in regressing myocardial fibrosis in hypertension: a prospective, randomized, open-label, blinded endpoint clinical trial protocol
BackgroundDiffuse interstitial myocardial fibrosis is a key common pathological manifestation in hypertensive heart disease (HHD) progressing to heart failure (HF). Angiotensin receptorâneprilysin inhibitors (ARNi), now a front-line treatment for HF, confer benefits independent of blood pressure, signifying a multifactorial mode of action beyond hemodynamic regulation. We aim to test the hypothesis that compared with angiotensin II receptor blockade (ARB) alone, ARNi is more effective in regressing diffuse interstitial myocardial fibrosis in HHD.MethodsRole of ARNi in Ventricular Remodeling in Hypertensive LVH (REVERSE-LVH) is a prospective, randomized, open-label, blinded endpoint (PROBE) clinical trial. Adults with hypertension and left ventricular hypertrophy (LVH) according to Asian sex- and age-specific thresholds on cardiovascular magnetic resonance (CMR) imaging are randomized to treatment with either sacubitril/valsartan (an ARNi) or valsartan (an ARB) in 1:1 ratio for a duration of 52 weeks, at the end of which a repeat CMR is performed to assess differential changes from baseline between the two groups. The primary endpoint is the change in CMR-derived diffuse interstitial fibrosis volume. Secondary endpoints include changes in CMR-derived left ventricular mass, volumes, and functional parameters. Serum samples are collected and stored to assess the effects of ARNi, compared with ARB, on circulating biomarkers of cardiac remodeling. The endpoints will be analyzed with reference to the corresponding baseline parameters to evaluate the therapeutic effect of sacubitril/valsartan vs. valsartan.DiscussionREVERSE-LVH will examine the anti-fibrotic potential of sacubitril/valsartan and will offer mechanistic insights into the clinical benefits of sacubitril/valsartan in hypertension in relation to cardiac remodeling. Advancing the knowledge of the pathophysiology of HHD will consolidate effective risk stratification and personalized treatment through a multimodal manner integrating complementary CMR and biomarkers into the conventional care approach.Clinical Trial Registration: ClinicalTrials.gov, identifier, NCT03553810
Noninvasive techniques for tracking biological aging of the cardiovascular system
Population aging is one of the most important demographic transformations of our time. Increasing the âhealth spanââthe proportion of life spent in good healthâis a global priority. Biological aging comprises molecular and cellular modifications over many years, which culminate in gradual physiological decline across multiple organ systems and predispose to age-related illnesses. Cardiovascular disease is a major cause of ill health and premature death in older people. The rate at which biological aging occurs varies across individuals of the same age and is influenced by a wide range of genetic and environmental exposures. The authors review the hallmarks of biological cardiovascular aging and their capture using imaging and other noninvasive techniques and examine how this information may be used to understand aging trajectories, with the aim of guiding individual- and population-level interventions to promote healthy aging
Exaggerated elastin turnover in young individuals with Marfan Syndrome â new insights from the AIMS trial
Background and aims: The fragmentation and loss of elastic fibre in the tunica media of the aorta is a pathological hallmark of Marfan syndrome (MFS) but the dynamics of elastin degradation and its relationship to aortic size and physiological growth remain poorly understood.Methods: In this post-hoc analysis of the AIMS randomised-controlled trial, the association of plasma desmosine (pDES) - a specific biomarker of mature elastin degradation - with age and aortic size was analysed in 113 patients with MFS and compared to 109 healthy controls.Results: There was a strong association between age and pDES in both groups, with higher pDES levels in the lower age groups compared to adults. During childhood, pDES increased and peaked during early adolescence, and thereafter decreased to lower adult levels. This trend was exaggerated in young individuals with MFS but in those above 25 years of age, pDES levels were comparable to controls despite the presence of aortic root dilation. In MFS children, increased aortic diameter relative to controls was seen at an early age and although the increase in diameter was less after adolescence, aortic root size continued to increase steadily with age. In MFS participants there was an indication of a positive association between baseline pDES levels and aortic root dilatation during up to 5 years of follow up.Conclusion: This study has shown that developmental age has a significant effect on levels of elastin turnover as measured by pDES in MFS individuals as well as healthy controls. This effect is exaggerated in those with MFS with increased levels seen during the period of physiologic development which plateaus towards adulthood. This suggests an early onset of pathophysiology that may present an important opportunity for disease modifying intervention
Myocardial Fibrosis and Cardiac Decompensation in Aortic Stenosis
OBJECTIVES: Cardiac magnetic resonance (CMR) was used to investigate the extracellular compartment and myocardial fibrosis in patients with aortic stenosis, as well as their association with other measures of left ventricular decompensation and mortality. BACKGROUND: Progressive myocardial fibrosis drives the transition from hypertrophy to heart failure in aortic stenosis. Diffuse fibrosis is associated with extracellular volume expansion that is detectable by T1 mapping, whereas late gadolinium enhancement (LGE) detects replacement fibrosis. METHODS: In a prospective observational cohort study, 203 subjects (166 with aortic stenosis [69 years; 69% male]; 37 healthy volunteers [68 years; 65% male]) underwent comprehensive phenotypic characterization with clinical imaging and biomarker evaluation. On CMR, we quantified the total extracellular volume of the myocardium indexed to body surface area (iECV). The iECV upper limit of normal from the control group (22.5 ml/m(2)) was used to define extracellular compartment expansion. Areas of replacement mid-wall LGE were also identified. All-cause mortality was determined during 2.9 ± 0.8 years of follow up. RESULTS: iECV demonstrated a good correlation with diffuse histological fibrosis on myocardial biopsies (r = 0.87; p < 0.001; n = 11) and was increased in patients with aortic stenosis (23.6 ± 7.2 ml/m(2) vs. 16.1 ± 3.2 ml/m(2) in control subjects; p < 0.001). iECV was used together with LGE to categorize patients with normal myocardium (iECV <22.5 ml/m(2); 51% of patients), extracellular expansion (iECV â„22.5 ml/m(2); 22%), and replacement fibrosis (presence of mid-wall LGE, 27%). There was evidence of increasing hypertrophy, myocardial injury, diastolic dysfunction, and longitudinal systolic dysfunction consistent with progressive left ventricular decompensation (all p < 0.05) across these groups. Moreover, this categorization was of prognostic value with stepwise increases in unadjusted all-cause mortality (8 deaths/1,000 patient-years vs. 36 deaths/1,000 patient-years vs. 71 deaths/1,000 patient-years, respectively; p = 0.009). CONCLUSIONS: CMR detects ventricular decompensation in aortic stenosis through the identification of myocardial extracellular expansion and replacement fibrosis. This holds major promise in tracking myocardial health in valve disease and for optimizing the timing of valve replacement. (The Role of Myocardial Fibrosis in Patients With Aortic Stenosis; NCT01755936)
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